Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Marginal zone (MZ) B cells produce a first wave of antibodies for protection from blood-borne pathogens. However, the role of MZ B cells in inflammatory responses has not been elucidated. Here we show that MZ B cells produce pro-inflammatory cytokines, such as interleukin-6 (IL-6), and exacerbate sy...

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Udgivet i:Nat Commun
Main Authors: Honda, Shin-ichiro, Sato, Kazuki, Totsuka, Naoya, Fujiyama, Satoshi, Fujimoto, Manabu, Miyake, Kensuke, Nakahashi-Oda, Chigusa, Tahara-Hanaoka, Satoko, Shibuya, Kazuko, Shibuya, Akira
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858745/
https://ncbi.nlm.nih.gov/pubmed/27146354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11498
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