Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

BACKGROUND: Hepatotoxicity accounts for a substantial number of drugs being withdrawn from the market. Using traditional animal models to detect hepatotoxicity is expensive and time-consuming. Alternative in vitro methods, in particular cell-based high-throughput screening (HTS) studies, have provid...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Environ Health Perspect
Autori principali: Kim, Marlene Thai, Huang, Ruili, Sedykh, Alexander, Wang, Wenyi, Xia, Menghang, Zhu, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Institute of Environmental Health Sciences 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858396/
https://ncbi.nlm.nih.gov/pubmed/26383846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1509763
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