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Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins

DFsc (single-chain due ferri) proteins allow for modeling binuclear non-heme iron enzymes with a similar fold. Three 4A → 4G variants of DFsc were studied to investigate the effects of (1) increasing the size of the substrate/solvent access channel (G4DFsc), (2) including an additional His residue i...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Snyder, Rae Ana, Betzu, Justine, Butch, Susan E., Reig, Amanda J., DeGrado, William F., Solomon, Edward I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857603/
https://ncbi.nlm.nih.gov/pubmed/26154739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00324
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