Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus–Responsive CD4(+) and CD8(+) T Cells at the Human Intestinal Mucosa

Background. Oral vaccination with live-attenuated Salmonella Typhi strain Ty21a is modestly efficacious, but the mechanisms of protection are currently unknown. While humoral and cellular immune responses are well described in peripheral blood, the cellular response at the intestinal mucosa has neve...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Pennington, Shaun H., Thompson, Ameeka L., Wright, Adam K. A., Ferreira, Daniela M., Jambo, Kondwani C., Wright, Angela D., Faragher, Brian, Gilmour, Jill W., Gordon, Stephen B., Gordon, Melita A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857474/
https://ncbi.nlm.nih.gov/pubmed/26810369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw030
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