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Analytic framework for peptidomics applied to large-scale neuropeptide identification

Large-scale mass spectrometry-based peptidomics for drug discovery is relatively unexplored because of challenges in peptide degradation and identification following tissue extraction. Here we present a streamlined analytical pipeline for large-scale peptidomics. We developed an optimized sample pre...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Secher, Anna, Kelstrup, Christian D., Conde-Frieboes, Kilian W., Pyke, Charles, Raun, Kirsten, Wulff, Birgitte S., Olsen, Jesper V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857386/
https://ncbi.nlm.nih.gov/pubmed/27142507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11436
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