Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice

Adoptive cell transfer (ACT) melanoma immunotherapy typically employs acutely activated effector CD8+ T cells for their ability to rapidly recognize and clear antigen. We have previously observed that effector CD8+ T cells are highly susceptible to melanoma-induced suppression, whereas memory CD8+ T...

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Détails bibliographiques
Publié dans:Cancer Immunol Immunother
Auteurs principaux: Contreras, Amanda, Sen, Siddhartha, Tatar, Andrew J., Mahvi, David A., Meyers, Justin V., Srinand, Prakrithi, Suresh, Marulasiddappa, Cho, Clifford S.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857203/
https://ncbi.nlm.nih.gov/pubmed/27011014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1823-8
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