Integrin α2 Mediates Selective Metastasis to the Liver

Cancers display distinct patterns of organ-specific metastasis. Comparative analysis of a broad array of cell membrane molecules on a liver-metastasizing subline of B16 melanoma versus the parental B16-F0 revealed unique up-regulation of integrin α2. The direct role of integrin α2 in hepatic metasta...

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Udgivet i:Cancer Res
Main Authors: Yoshimura, Kiyoshi, Meckel, Kristen F., Laird, Lindsay S., Chia, Christina Y., Park, Jang-June, Olino, Kelly L., Tsunedomi, Ryouichi, Harada, Toshio, Iizuka, Norio, Hazama, Shoichi, Kato, Yukihiko, Keller, Jesse W., Thompson, John M., Chang, Fumin, Romer, Lewis H., Jain, Ajay, Iacobuzio-Donahue, Christine, Oka, Masaaki, Pardoll, Drew M., Schulick, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857201/
https://ncbi.nlm.nih.gov/pubmed/19738067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0315
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