The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons

We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA turnover, the total mRNA concentration remained approximately constant. Some gen...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: García-Martínez, José, Delgado-Ramos, Lidia, Ayala, Guillermo, Pelechano, Vicent, Medina, Daniel A., Carrasco, Fany, González, Ramón, Andrés-León, Eduardo, Steinmetz, Lars, Warringer, Jonas, Chávez, Sebastián, Pérez-Ortín, José E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856968/
https://ncbi.nlm.nih.gov/pubmed/26717982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1512
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