The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons

We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA turnover, the total mRNA concentration remained approximately constant. Some gen...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: García-Martínez, José, Delgado-Ramos, Lidia, Ayala, Guillermo, Pelechano, Vicent, Medina, Daniel A., Carrasco, Fany, González, Ramón, Andrés-León, Eduardo, Steinmetz, Lars, Warringer, Jonas, Chávez, Sebastián, Pérez-Ortín, José E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856968/
https://ncbi.nlm.nih.gov/pubmed/26717982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1512
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