A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

BACKGROUND: Toll-like receptor 4 (TLR4) plays a pivotal role in the pathophysiology of stroke-induced inflammation. Both astroglia and microglia express TLR4, and endogenous ligands produced in the ischemic brain induce inflammatory responses. Reactive oxygen species (ROS), nitric oxide (NO), and in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neuroinflammation
Prif Awduron: Iizumi, Takuya, Takahashi, Shinichi, Mashima, Kyoko, Minami, Kazushi, Izawa, Yoshikane, Abe, Takato, Hishiki, Takako, Suematsu, Makoto, Kajimura, Mayumi, Suzuki, Norihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855896/
https://ncbi.nlm.nih.gov/pubmed/27143001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0564-0
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