Defining a COPD composite safety endpoint for demonstrating efficacy in clinical trials: results from the randomized, placebo-controlled UPLIFT® trial

BACKGROUND: Chronic obstructive pulmonary disease (COPD) clinical trials evaluating hard endpoints (mortality, hospitalized exacerbations) require a large number of subjects and prolonged observational periods. We hypothesized that a composite endpoint of respiratory outcomes (CERO) can help evaluat...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Celli, Bartolomé R., Decramer, Marc, Liu, Dacheng, Metzdorf, Norbert, Asijee, Guus M., Tashkin, Donald P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855862/
https://ncbi.nlm.nih.gov/pubmed/27141828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0361-4
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