Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis

Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. In this paper, we report the production of mammospheres from three lines of TNBC cells and demonstrate that both parthenolide (PN) and its soluble analog dimethylaminoparthenoli...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Carlisi, D, Buttitta, G, Di Fiore, R, Scerri, C, Drago-Ferrante, R, Vento, R, Tesoriere, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855673/
https://ncbi.nlm.nih.gov/pubmed/27077810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.94
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