The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing

In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by α-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative cell death. We performed genetic screen of a knockdown (KD) fly library by measuring the r...

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Vydáno v:Cell Death Dis
Hlavní autoři: Mao, Y, Tamura, T, Yuki, Y, Abe, D, Tamada, Y, Imoto, S, Tanaka, H, Homma, H, Tagawa, K, Miyano, S, Okazawa, H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855646/
https://ncbi.nlm.nih.gov/pubmed/27124581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.101
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