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Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity
To fortify their cytoplasmic membrane and protect it from osmotic rupture, most bacteria surround themselves with a peptidoglycan (PG) exoskeleton synthesized by the penicillin-binding proteins (PBPs). As their name implies, these proteins are the targets of penicillin and related antibiotics. We an...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4855605/ https://ncbi.nlm.nih.gov/pubmed/27071112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524538113 |
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