Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

To fortify their cytoplasmic membrane and protect it from osmotic rupture, most bacteria surround themselves with a peptidoglycan (PG) exoskeleton synthesized by the penicillin-binding proteins (PBPs). As their name implies, these proteins are the targets of penicillin and related antibiotics. We an...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Markovski, Monica, Bohrhunter, Jessica L., Lupoli, Tania J., Uehara, Tsuyoshi, Walker, Suzanne, Kahne, Daniel E., Bernhardt, Thomas G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855605/
https://ncbi.nlm.nih.gov/pubmed/27071112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524538113
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