Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis, a severe invasive disease of humans and animals. Initial screening of a B. pseudomallei signature-tagged mutagenesis library identified an attenuated mutant with a transposon insertion in a gene encoding the sensor componen...

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Udgivet i:BMC Genomics
Main Authors: Lazar Adler, Natalie R., Allwood, Elizabeth M., Deveson Lucas, Deanna, Harrison, Paul, Watts, Stephen, Dimitropoulos, Alexandra, Treerat, Puthayalai, Alwis, Priyangi, Devenish, Rodney J., Prescott, Mark, Govan, Brenda, Adler, Ben, Harper, Marina, Boyce, John D.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855414/
https://ncbi.nlm.nih.gov/pubmed/27147217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2668-4
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