AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis

Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is one such modification. The human lens capsule is a BM secreted by lens epithelial cells. In this study, we have investigated the effect of aging and...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Raghavan, Cibin T., Smuda, Mareen, Smith, Andrew J. O., Howell, Scott, Smith, Dawn G., Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A., Wormstone, Ian Michael, Nagaraj, Ram H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854921/
https://ncbi.nlm.nih.gov/pubmed/26853893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12450
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