Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age‐related chronic disease. However, the molecular mechanisms underlying this phenotype are unkno...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Noren Hooten, Nicole, Martin‐Montalvo, Alejandro, Dluzen, Douglas F., Zhang, Yongqing, Bernier, Michel, Zonderman, Alan B., Becker, Kevin G., Gorospe, Myriam, de Cabo, Rafael, Evans, Michele K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854919/
https://ncbi.nlm.nih.gov/pubmed/26990999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12469
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