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The anti-tumor efficacy of IL-2/IL-21-cultured polyfunctional neu-specific T-cells is TNF-alpha/IL-17 dependent

PURPOSE: Infusion of HER2 specific T-cells, derived from vaccine-primed patients and expanded with IL-2/IL-12, has induced tumor regression in a minority of patients with metastatic treatment-refractory HER2+ breast cancer. We questioned whether alteration of cytokine growth factors used to culture...

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Bibliografski detalji
Izdano u:Clin Cancer Res
Glavni autori: Phan-Lai, Vy, Dang, Yushe, Gad, Ekram, Childs, Jennifer, Disis, Mary L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854769/
https://ncbi.nlm.nih.gov/pubmed/26660518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2273
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