Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p

To ascertain the epigenomic features, i.e., the methylation, non-coding RNA, and gene expression patterns, associated with gain of i(12p) in Pallister-Killian syndrome (PKS), we investigated single cell clones, harboring either disomy 12 or tetrasomy 12p, from a patient with PKS. The i(12p)-positive...

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Vydáno v:Epigenetics
Hlavní autoři: Davidsson, Josef, Johansson, Bertil
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854541/
https://ncbi.nlm.nih.gov/pubmed/26890086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1146854
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