Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site

MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, regulation of transcription and development. As a member of the MAP kinase family, ERK5 (MAPK7) is involved in the downstream sign...

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Vydáno v:Acta Crystallogr D Struct Biol
Hlavní autoři: Chen, Hongming, Tucker, Julie, Wang, Xiaotao, Gavine, Paul R., Phillips, Chris, Augustin, Martin A., Schreiner, Patrick, Steinbacher, Stefan, Preston, Marian, Ogg, Derek
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2016
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854315/
https://ncbi.nlm.nih.gov/pubmed/27139631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798316004502
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