Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disorder characterized by the proliferation of interstitial fibroblasts and the deposition of extracellular matrix causing impaired gas exchange. Spiruchostatin A (SpA) is a histone deacetylase inhibitor (HDI) with selectivity toward Clas...

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Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Davies, Elizabeth R., Haitchi, Hans Michael, Thatcher, Thomas H., Sime, Patricia J., Kottmann, R. Matthew, Ganesan, Arasu, Packham, Graham, O'Reilly, Katherine M. A., Davies, Donna E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854311/
https://ncbi.nlm.nih.gov/pubmed/22246864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0040OC
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