Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype

Cellular microRNAs (miRNAs) are able to influence hepatitis B virus (HBV) replication directly by binding to HBV transcripts or indirectly by targeting cellular factors. Here, we investigate the effect of epigenetically regulated miR-449a on HBV replication and the underlying mechanisms. miR-449a ex...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Xiaoyong, Liu, Hongyan, Xie, Zhanglian, Deng, Wangyu, Wu, Chunchen, Qin, Bo, Hou, Jinlin, Lu, Mengji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853741/
https://ncbi.nlm.nih.gov/pubmed/27138288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25389
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