IL-25/IL-33–responsive T(H)2 cells characterize nasal polyps with a default T(H)17 signature in nasal mucosa

BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in Western countries is characterized by eosinophilia, IgE production, and T(H)2 cytokine expression. Type 2 innate lymphoid cells from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33, although the relevance of this axis t...

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Bibliografske podrobnosti
izdano v:J Allergy Clin Immunol
Main Authors: Lam, Emily P.S., Kariyawasam, Harsha H., Rana, Batika M.J., Durham, Stephen R., McKenzie, Andrew N.J., Powell, Nicholas, Orban, Nara, Lennartz-Walker, Melissa, Hopkins, Claire, Ying, Sun, Rimmer, Joanne, Lund, Valerie J., Cousins, David J., Till, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Mosby 2016
Teme:
Mechanisms of Allergy and Clinical Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852988/
https://ncbi.nlm.nih.gov/pubmed/26684290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.10.019
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