Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein

OBJECTIVE: Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit. Papaverine is a nonspecific inhibitor of phosphodiesterases, leading to increases in both intracellular cGMP and cAMP. We hypothesized that papav...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Hocking, Kyle M., Putumbaka, Gowthami, Wise, Eric S., Cheung-Flynn, Joyce, Brophy, Colleen M., Komalavilas, Padmini
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852981/
https://ncbi.nlm.nih.gov/pubmed/27136356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154460
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