Oxidized LDL-bound CD36 recruits a Na(+)/K(+)-ATPase-Lyn complex in macrophages that promotes atherosclerosis

One characteristic of atherosclerosis is the accumulation of lipid-laden macrophage foam cells in the arterial wall. We have previously shown that the binding of oxidized LDL (oxLDL) to the scavenger receptor CD36 activates the kinase Lyn, initiating a cascade that inhibits macrophage migration and...

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Pubblicato in:Sci Signal
Autori principali: Chen, Yiliang, Kennedy, David J., Ramakrishnan, Devi Prasadh, Yang, Moua, Huang, Wenxin, Li, Zhichuan, Xie, Zijian, Chadwick, Alexandra C., Sahoo, Daisy, Silverstein, Roy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852751/
https://ncbi.nlm.nih.gov/pubmed/26350901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa9623
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