Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchro...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Atkinson, Sara Marie, Hoffmann, Ute, Hamann, Alf, Bach, Emil, Danneskiold-Samsøe, Niels Banhos, Kristiansen, Karsten, Serikawa, Kyle, Fox, Brian, Kruse, Kim, Haase, Claus, Skov, Søren, Nansen, Anneline
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852503/
https://ncbi.nlm.nih.gov/pubmed/26822477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022905
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