ACTH Prevents Deficits in Fear Extinction Associated with Early Life Seizures

OBJECTIVE: Early life seizures (ELS) are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of ELS, we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous HPA-axis hormone given to children with severe epi...

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Veröffentlicht in:Front Neurol
Hauptverfasser: Massey, Andrew T., Lerner, David K., Holmes, Gregory L., Scott, Rod C., Hernan, Amanda E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852169/
https://ncbi.nlm.nih.gov/pubmed/27199888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2016.00065
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