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Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Bacimethrin (4-amino-5-hydroxymethyl-2-methoxypyrimidine), a natural product isolated from some bacteria, has been implicated as an inhibitor of bacterial and yeast growth, as well as in inhibition of thiamin biosynthesis. Given that thiamin biosynthetic enzymes could convert bacimethrin to 2′-metho...

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Bibliografiska uppgifter
I publikationen:Biochemistry
Huvudupphovsmän: Nemeria, Natalia S., Shome, Brateen, DeColli, Alicia A., Heflin, Kathryn, Begley, Tadhg P., Meyers, Caren Freel, Jordan, Frank
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852132/
https://ncbi.nlm.nih.gov/pubmed/26813608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01300
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