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Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Bacimethrin (4-amino-5-hydroxymethyl-2-methoxypyrimidine), a natural product isolated from some bacteria, has been implicated as an inhibitor of bacterial and yeast growth, as well as in inhibition of thiamin biosynthesis. Given that thiamin biosynthetic enzymes could convert bacimethrin to 2′-metho...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Biochemistry
Main Authors: Nemeria, Natalia S., Shome, Brateen, DeColli, Alicia A., Heflin, Kathryn, Begley, Tadhg P., Meyers, Caren Freel, Jordan, Frank
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852132/
https://ncbi.nlm.nih.gov/pubmed/26813608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01300
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