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Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Bacimethrin (4-amino-5-hydroxymethyl-2-methoxypyrimidine), a natural product isolated from some bacteria, has been implicated as an inhibitor of bacterial and yeast growth, as well as in inhibition of thiamin biosynthesis. Given that thiamin biosynthetic enzymes could convert bacimethrin to 2′-metho...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Nemeria, Natalia S., Shome, Brateen, DeColli, Alicia A., Heflin, Kathryn, Begley, Tadhg P., Meyers, Caren Freel, Jordan, Frank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852132/
https://ncbi.nlm.nih.gov/pubmed/26813608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01300
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