mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

It has been established that mammalian target of Rapamycin (mTOR) inhibitors have anti-inflammatory effects in models of experimental colitis. However, the underlying mechanism is largely unknown. In this research, we investigate the anti-inflammatory effects of AZD8055, a potent mTOR inhibitor, on...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hu, Shurong, Chen, Mengmeng, Wang, Yilin, Wang, Zhengting, Pei, Yaofei, Fan, Rong, Liu, Xiqiang, Wang, Lei, Zhou, Jie, Zheng, Sichang, Zhang, Tianyu, Lin, Yun, Zhang, Maochen, Tao, Ran, Zhong, Jie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851424/
https://ncbi.nlm.nih.gov/pubmed/27128484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154564
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