Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes

Retinoblastoma is a rare childhood cancer initiated by RB1 mutation or MYCN amplification, while additional alterations may be required for tumor development. However, the view on single nucleotide variants is very limited. To better understand oncogenesis, we determined the genomic landscape of ret...

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Publicado no:Sci Rep
Main Authors: Kooi, Irsan E., Mol, Berber M., Massink, Maarten P. G., Ameziane, Najim, Meijers-Heijboer, Hanne, Dommering, Charlotte J., van Mil, Saskia E., de Vries, Yne, van der Hout, Annemarie H., Kaspers, Gertjan J. L., Moll, Annette C., te Riele, Hein, Cloos, Jacqueline, Dorsman, Josephine C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850475/
https://ncbi.nlm.nih.gov/pubmed/27126562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25264
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