Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes

Retinoblastoma is a rare childhood cancer initiated by RB1 mutation or MYCN amplification, while additional alterations may be required for tumor development. However, the view on single nucleotide variants is very limited. To better understand oncogenesis, we determined the genomic landscape of ret...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kooi, Irsan E., Mol, Berber M., Massink, Maarten P. G., Ameziane, Najim, Meijers-Heijboer, Hanne, Dommering, Charlotte J., van Mil, Saskia E., de Vries, Yne, van der Hout, Annemarie H., Kaspers, Gertjan J. L., Moll, Annette C., te Riele, Hein, Cloos, Jacqueline, Dorsman, Josephine C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850475/
https://ncbi.nlm.nih.gov/pubmed/27126562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25264
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