Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells

ARID1A is a tumor suppressor gene that belongs to the switch/sucrose non-fermentable chromatin remodeling gene family. It is mutated in many types of human cancer with the highest frequency in endometrium-related ovarian and uterine neoplasms including ovarian clear cell, ovarian endometrioid, and u...

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Vydáno v:J Biol Chem
Hlavní autoři: Rahmanto, Yohan Suryo, Jung, Jin-Gyoung, Wu, Ren-Chin, Kobayashi, Yusuke, Heaphy, Christopher M., Meeker, Alan K., Wang, Tian-Li, Shih, Ie-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850306/
https://ncbi.nlm.nih.gov/pubmed/26953344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707612
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