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Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration

PURPOSE: The purpose of this study was to investigate the effect of the antiviral drug ganciclovir (GCV) on Müller glia dedifferentiation and proliferation and the underlying cellular and molecular mechanisms in adult zebrafish. METHODS: A Tg(1016tuba1a:GFP) transgenic line was generated to identify...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Zhang, Shuqiang, Mu, Zhaoxia, He, Chunjiao, Zhou, Minmin, Liu, Dong, Zhao, Xiao-Feng, Goldman, Daniel, Xu, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849886/
https://ncbi.nlm.nih.gov/pubmed/27096757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18669
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