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Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration

PURPOSE: The purpose of this study was to investigate the effect of the antiviral drug ganciclovir (GCV) on Müller glia dedifferentiation and proliferation and the underlying cellular and molecular mechanisms in adult zebrafish. METHODS: A Tg(1016tuba1a:GFP) transgenic line was generated to identify...

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Dettagli Bibliografici
Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Zhang, Shuqiang, Mu, Zhaoxia, He, Chunjiao, Zhou, Minmin, Liu, Dong, Zhao, Xiao-Feng, Goldman, Daniel, Xu, Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849886/
https://ncbi.nlm.nih.gov/pubmed/27096757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18669
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