Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension

Tacrolimus is a widely used immunosuppressive drug that inhibits the phosphatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12). When this binding occurs in T cells, it leads to immunosuppression. Tacrolimus also causes side effects, however, such as hypertension and hyperkalemi...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Lazelle, Rebecca A., McCully, Belinda H., Terker, Andrew S., Himmerkus, Nina, Blankenstein, Katharina I., Mutig, Kerim, Bleich, Markus, Bachmann, Sebastian, Yang, Chao-Ling, Ellison, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2016
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849833/
https://ncbi.nlm.nih.gov/pubmed/26432904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015040466
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