Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

INTRODUCTION: Initial evaluation of a candidate vaccine against HIV includes an assessment of the vaccine’s ability to generate immune responses. However, the dynamics of vaccine-induced immune responses are unclear. We hypothesized that the IFN-γ producing cytotoxic CD8+ (CD8+ IFN-γ+) T cell respon...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lhomme, Edouard, Richert, Laura, Moodie, Zoe, Pasin, Chloé, Kalams, Spyros A., Morgan, Cecilia, Self, Steve, De Rosa, Stephen C., Thiébaut, Rodolphe
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849671/
https://ncbi.nlm.nih.gov/pubmed/27124598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152952
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