Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a renal syndrome characterized by proteinuria, renal failure, and focal segmental glomerulosclerosis. By using a noninfectious HIV-1 DNA construct lacking the gag and pol genes, three transgenic mouse lines have been generate...

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Main Authors: Kopp, J B, Klotman, M E, Adler, S H, Bruggeman, L A, Dickie, P, Marinos, N J, Eckhaus, M, Bryant, J L, Notkins, A L, Klotman, P E
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC48495/
https://ncbi.nlm.nih.gov/pubmed/1542649
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