In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the...

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Publicat a:Int J Mol Sci
Autors principals: Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849040/
https://ncbi.nlm.nih.gov/pubmed/27092500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17040584
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