In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849040/
https://ncbi.nlm.nih.gov/pubmed/27092500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17040584
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