Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, we used whole-genome sequences from 498 strains of M. tuberculosis to identif...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Desjardins, Christopher A., Cohen, Keira A., Munsamy, Vanisha, Abeel, Thomas, Maharaj, Kashmeel, Walker, Bruce J., Shea, Terrance P., Almeida, Deepak V., Manson, Abigail L., Salazar, Alex, Padayatchi, Nesri, O’Donnell, Max R., Mlisana, Koleka P., Wortman, Jennifer, Birren, Bruce W., Grosset, Jacques, Earl, Ashlee M., Pym, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848111/
https://ncbi.nlm.nih.gov/pubmed/27064254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3548
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