The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study

Angiotensin-I-converting enzyme (ACE) inhibitors are an important class of antihypertensives whose action on the human organism is still not fully understood. Although it is known that ACE especially cleaves COOH-terminal dipeptides from active polypeptides, the whole range of substrates and product...

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Veröffentlicht in:PLoS One
Hauptverfasser: Altmaier, Elisabeth, Menni, Cristina, Heier, Margit, Meisinger, Christa, Thorand, Barbara, Quell, Jan, Kobl, Michael, Römisch-Margl, Werner, Valdes, Ana M., Mangino, Massimo, Waldenberger, Melanie, Strauch, Konstantin, Illig, Thomas, Adamski, Jerzy, Spector, Tim, Gieger, Christian, Suhre, Karsten, Kastenmüller, Gabi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847917/
https://ncbi.nlm.nih.gov/pubmed/27120469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153163
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