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New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Polman, David J., Price, Douglas K., Figg, William D.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847822/
https://ncbi.nlm.nih.gov/pubmed/26552331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1108498
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