Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro

BACKGROUND: TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via induction of immunesuppressive cytokines and indoleamine 2,3-dioxygenase (IDO). Atractylenolide I (AO-1) is a naturally occurring sesq...

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Detalles Bibliográficos
Publicado en:J Transl Med
Main Authors: Liu, Hong, Zhang, Guonan, Huang, Jianming, Ma, Shiqi, Mi, Kun, Cheng, Jia, Zhu, Yi, Zha, Xiao, Huang, Wei
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847224/
https://ncbi.nlm.nih.gov/pubmed/27118139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0845-5
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