In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

According to in vitro assays, T cells are thought to kill rapidly and efficiently, but the efficacy and dynamics of cytotoxic T lymphocyte (CTL)-mediated killing of virus-infected cells in vivo remains elusive. We used two-photon microscopy to quantify CTL-mediated killing in mice infected with herp...

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Publicado no:Immunity
Main Authors: Halle, Stephan, Keyser, Kirsten Anja, Stahl, Felix Rolf, Busche, Andreas, Marquardt, Anja, Zheng, Xiang, Galla, Melanie, Heissmeyer, Vigo, Heller, Katrin, Boelter, Jasmin, Wagner, Karen, Bischoff, Yvonne, Martens, Rieke, Braun, Asolina, Werth, Kathrin, Uvarovskii, Alexey, Kempf, Harald, Meyer-Hermann, Michael, Arens, Ramon, Kremer, Melanie, Sutter, Gerd, Messerle, Martin, Förster, Reinhold
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846978/
https://ncbi.nlm.nih.gov/pubmed/26872694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.01.010
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