Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2

Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not fully understood yet. Here we identify Ndrg1 as an anergy factor induced by Egr2. Ndrg1 is upregulated by a...

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Publicado no:Nat Commun
Main Authors: Oh, Yu Mi, Park, Hyung Bae, Shin, Jae Hun, Lee, Ji Eun, Park, Ha Young, Kho, Dhong Hyo, Lee, Jun Sung, Choi, Heonsik, Okuda, Tomohiko, Kokame, Koichi, Miyata, Toshiyuki, Kim, In-Hoo, Lee, Seung Hoon, Schwartz, Ronald H., Choi, Kyungho
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846325/
https://ncbi.nlm.nih.gov/pubmed/26507712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9698
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