POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation

Hyperactivation of the transcriptional factor E2F1 occurs frequently in human cancers and contributes to malignant progression. E2F1 activity is regulated by proteolysis mediated by the ubiquitin–proteasome system. However, the deubiquitylase that controls E2F1 ubiquitylation and stability remains u...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Boshi, Ma, Aihui, Zhang, Li, Jin, Wei-Lin, Qian, Yu, Xu, Guiqin, Qiu, Bijun, Yang, Zhaojuan, Liu, Yun, Xia, Qiang, Liu, Yongzhong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846323/
https://ncbi.nlm.nih.gov/pubmed/26510456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9704
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