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Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and l-citrulline formation
The benzoquinone derivative embelin is a multifunctional drug that not only induces apoptosis by inhibiting XIAP, the X chromosome-linked inhibitor of apoptosis protein, but also blocks nuclear factor-κB signaling pathways, thereby leading to down-regulation of a variety of gene products involved in...
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| Veröffentlicht in: | Nitric Oxide |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845887/ https://ncbi.nlm.nih.gov/pubmed/20144727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2010.02.001 |
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