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Many multicentre trials had few events per centre, requiring analysis via random-effects models or GEEs
OBJECTIVES: Adjustment for center in multicenter trials is recommended when there are between-center differences or when randomization has been stratified by center. However, common methods of analysis (such as fixed-effects, Mantel-Haenszel, or stratified Cox models) often require a large number of...
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| Publicado no: | J Clin Epidemiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845666/ https://ncbi.nlm.nih.gov/pubmed/25985892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2015.03.016 |
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