Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

Vulnerability of specific brain regions and neuronal populations is a characteristic feature of Alzheimer disease and Down syndrome. Cholinergic neurons of the basal forebrain degenerate in both disorders. The basis for neuronal degeneration is unknown. Mouse trisomy 16 (Ts 16) is an animal model of...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Holtzman, D M, Li, Y W, DeArmond, S J, McKinley, M P, Gage, F H, Epstein, C J, Mobley, W C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741393/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.4.1383
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