Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro

BACKGROUND: For Glioblastoma (GBM) patients, a number of anti-neoplastic strategies using specifically targeting drugs have been tested; however, the effects on survival have been limited. One explanation could be treatment resistance due to redundant signaling pathways, which substantiates the need...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Cell Int
Hauptverfasser: Staberg, Mikkel, Michaelsen, Signe Regner, Olsen, Louise Stobbe, Nedergaard, Mette Kjølhede, Villingshøj, Mette, Stockhausen, Marie-Thérése, Hamerlik, Petra, Poulsen, Hans Skovgaard
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845362/
https://ncbi.nlm.nih.gov/pubmed/27118928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0309-2
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