The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43, encoded by TARDBP ) neuronal cytoplasmic inclusions are the pathological hallmark in ∼95% of amyotrophic lateral sclerosis and ∼60% of frontotemporal lobar degeneration cases. We sought to explore the role...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Chen, Han-Jou, Mitchell, Jacqueline C., Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline A., Cheetham, Michael E., Shaw, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845254/
https://ncbi.nlm.nih.gov/pubmed/26936937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww028
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