Identification of critical residues in Hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins

Hepatitis E virus (HEV) is a major cause of hepatitis in normal and organ transplant individuals. HEV open reading frame-1 encodes a polypeptide comprising of the viral nonstructural proteins as well as domains of unknown function such as the macro domain (X-domain), V, DUF3729 and Y. The macro doma...

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Pubblicato in:Sci Rep
Autori principali: Anang, Saumya, Subramani, Chandru, Nair, Vidya P., Kaul, Sheetal, Kaushik, Nidhi, Sharma, Chandresh, Tiwari, Ashutosh, Ranjith-Kumar, CT, Surjit, Milan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844956/
https://ncbi.nlm.nih.gov/pubmed/27113483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25133
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